To fight Delta, extend second-dose protection as quickly as possible: Study

Must read

Pixel 6 and 6 Pro to get new ‘Motif’ wallpapers [Gallery]

As the launch event for the Pixel 6 and 6 Pro grows nearer, Google continues to put finishing touches on the user experience....

Best Samsung Galaxy Z Flip 3 wireless chargers 2021

Best Samsung Galaxy Z Flip 3 wireless chargers Android Central 2021 The Samsung Galaxy Z Flip 3 is a slick little number, but its compact size and...

Forspoken release date, trailers, news and rumors

Forspoken is the name of the new action RPG from Square Enix formerly known as ‘Project Athia’ coming exclusively to PS5 and PC...
Bhawani Singh
I am a blogger who believes in delivering latest tech news from around the world to my viewers.

The Pfizer Covid vaccine is less effective against the Delta variant (also known as B.1.617.2) and that those with two doses would be better protected against the new strain, found a new study in Lancet.

Delta has been declared as Variant of Concern (VOC) by the World Health Organisation (WHO). First detected in India, the Delta variant is now dominant in the UK. It has displaced the B.1.1.7 (Alpha) strain 2 that emerged in the UK with the second Covid wave in late 2020.

Also Read | ‘Pfizer vaccine generates fewer antibodies against Delta variant’ 

The study said that the efficacy of Covid vaccines against B.1.617.2 was unknown so it carried out an initial analysis to track serological responses to vaccination.  

The study was conducted using Pfizer–BioNTech vaccine against five Covid strains, including variants of concerns B.1.617.2 (Delta) and B.1.351 (Beta) first detected in South Africa). The other three variants were: a strain with the original spike sequence (Wild-type); a strain with an Asp614Gly mutation isolated during the first wave of infection in the UK (D614G); and B.1.1.7 (Alpha). 

Also Read | Serum Institute gets DCGI’s nod to manufacture Covid vaccine Sputnik V in India: Report

The study found that two doses of Pfizer vaccine “elicited ELISA-detected anti-Wild-type spike antibodies” in all participants, and neutralising antibodies against all strains, including the three VOCs. However, six (3%) and nine (5%) of 159 participants lacked antibodies against B.1.617.2 and B.1.351, respectively.  

The study also compared the vaccine efficacy between the two doses.

According to the study, neutralisation of variants of concern was “markedly different” after only one dose of Pfizer vaccine. It also said that most participants who received two doses of Pfizer vaccine “would be protected against B.1.617.2 infection”. 

“In the case of two BNT162b2 (Pfizer) doses, our cohort of generally healthy, relatively young, recently vaccinated, and mostly single-ethnicity individuals presents a reasonable best-case scenario for NAb (neutralising antibodies) activity against SARS-CoV-2 variants,” the study said. It, however, added that regardless of the absolute vaccine efficacy requirements, “peak NAbTs (NAb titres) are significantly reduced against VOCs B.1.617.2 and B.1.351 compared with NAbTs against earlier variants”.

In the case of single-dose recipients, the study said, data showed that NAbTs were significantly lower against Delta and Beta variants relative to Alpha. “Single-dose recipients are likely to be less protected against these SARS-CoV-2 variants,” it said. 

“These data therefore suggest that the benefits of delaying the second dose, in terms of wider population coverage and increased individual NAbTs after the second dose, must now be weighed against decreased efficacy in the short-term, in the context of the spread of B.1.617.2,” the study said.

Earlier, the UK had extended the interval between the two doses to maximise population coverage. 

The study said that its data highlighted the need to increase vaccine supply to allow all countries “to extend second-dose protection as quickly as possible”.

On May 13, India extended the gap between the first and second doses of Covishield vaccine, manufactured by Serum Institute, to 12-16 weeks. Earlier, the gap was 6-8 weeks.

Subscribe to Mint Newsletters

* Enter a valid email

* Thank you for subscribing to our newsletter.

Never miss a story! Stay connected and informed with Mint.
our App Now!!

Source link

More articles

Leave a Reply

Subscribe to our newsletter

To be updated with all the latest news, offers and special announcements.

- Advertisement -

Latest article

YouTube Music to go audio-only for non-premium users

YouTube Music is soon going audio-only for free users and will no longer play music videos alongside the audio. The platform recently announced...

British entrepreneur sells company to Twitter

Nick D'Aloisio previously sold an app to Yahoo when he was only 17 years old. Source link

Assassin’s Creed Valhalla’s next expansion could take a leaf from God of War: Ragnarok

Assassin's Creed Valhalla's third expansion is on the way, and while we know little official information on the project, a well-known dataminer has...

Windows 11 Beta Testers Can Now Download Android Apps Through Microsoft Store

Windows 11 beta testers can now install Android apps on their systems directly through the Microsoft Store. The new experience comes months after...
- Advertisement -