Scientists decode how coronavirus interacts with proteins in human cells

Must read

How to disable and delete Samsung Pay from your Galaxy phone

When it comes to paying conveniently, Samsung Pay makes using your phone as a bank card an easy process; however, there may come...

Google Home 2.35 reveals possible Nest Hello successor

Version 2.35 of the Google Home app is rolling out on Android and iOS with some user-facing tweaks. The Home companion client today...

PS5 restock: Sony Direct has the console in stock today – get it right now

Update: Sony Direct has a PS5 restock right now, so may be able to buy the console right now. Of course, you'll have...

How to Hack the Hidden Google Chrome Dinosaur Game

Most of us have seen the dreaded “No Internet” error message on Google Chrome. You can actually turn this screen into a fun,...
Bhawani Singhhttps://techmepro.com
I am a blogger who believes in delivering latest tech news from around the world to my viewers.

BOSTON: Scientists have charted the first atlas showing how the genetic material of the novel coronavirus interacts with the proteins in human cells, an advance which may provide a starting point for the development of new treatments against Covid-19.
According to the researchers, including those from Broad Institute in the US, one of the most urgent tasks is to understand all the molecular interactions between the virus and the cells it infects.
They explained that a detailed understanding of these interactions will help identify the processes in host cells which favour the multiplication of the virus, and the ones which activate the host immune system.
While the SARS-CoV-2 virus uses host proteins to replicate, the scientists said until now, there has been no detailed understanding of all the proteins occurring in human cells which interact with the viral genetic material — its RNA.
In the current research, published in the journal Nature Microbiology, the scientists created the first global atlas of direct interactions between the SARS-CoV-2 RNA and the proteins present in human cells.
Based on the findings, the researchers also identified important regulators of viral replication.
The scientists infected human cells with the novel coronavirus, purified the viral RNA and identified the proteins bound to it.
“In this particular case, we were able to perform quantitative measurements to identify the strongest specific binding partners,” said study co-author Mathias Munschauer from the Helmholtz Institute for RNA-based Infection Research (HIRI) in Germany.
The scientists said the atlas of RNA-protein interactions offers unique insights into SARS-CoV-2 infections, enabling the systematic breakdown of factors influencing the replication of the virus, and host defense strategies — a crucial prerequisite for the development of new therapeutics.
From the results, the scientists identified 18 host proteins that play an important role during SARS-CoV-2 infection, and found 20 small molecules that may inhibit these proteins.
They believe the two proteins CNBP and LARP1 are particularly interesting.
The researchers also identified target sites in these proteins that could be used to inhibit the replication of the virus.
According to Munschauer, the characterization of LARP1 as an antiviral factor is a major finding.
“The way LARP1 binds to viral RNA is very interesting, because it is similar to the way LARP1 regulates certain cellular messenger RNAs that we already know. This in turn provides insights into possible mechanisms of action,” he added.
According to the scientists, three out of four small molecules they tested inhibited viral replication in different human cell types — findings that may open up new ways to treat Covid-19.

Source link


More articles

Leave a Reply

Subscribe to our newsletter

To be updated with all the latest news, offers and special announcements.

- Advertisement -

Latest article

The Telegram app now has a mysterious twin that you won’t find on the Play Store (APK Download)

Telegram has gathered steam over the last few months and it recently even updated its Telegram X application after leaving it in limbo...

Frames per Second: In custody, then and now

Anand Patwardhan's film Prisoner of Conscience, on political prisoners in India during the Emergency, has some deep resonances for our times Source link

Confused About The Janta Curfew In Maharashtra? Here Are Some Memes That Prove You’re Not Alone

Maharashtra has consistently been contributing in India’s daily count and total COVID-19 cases and there are no two ways about it....

Facebook is said to be working on a video dating app

NEW DELHI: Social networking giant Facebook is testing a new speed dating app called Sparked. The app has been developed by Facebook's internal...
- Advertisement -